He remained clinically improved for 19 a few months of treatment but required resection of his vestibular schwannoma for tumor development. Four of five individuals reported subjective improvement in baseline tinnitus, and something noted no change. Adverse Effects A total of 21 grade one or two 2 adverse events were reported, including increased levels of aspartate aminotransferase and alanine aminotransferase , proteinuria , hypertension , delayed wound therapeutic , hyperkalemia , hyperbilirubinemia , uterine bleeding , hypocalcemia , hypophosphatemia , and hypomagnesemia . Two individuals had infected vascular access ports needing removal.Secondary Outcomes In-hospital mortality and mortality at 6 months were considerably higher among individuals who received glutamine than among sufferers who did not receive glutamine . There were also significant increases in the median period to discharge alive from the ICU and the median period to discharge alive from the hospital among patients who received glutamine in comparison with those who didn’t . For outcomes in the four individual study-agent groups, see Table 2 in the Supplementary Appendix.