HENT1 on the cell membrane[ 1].

Elacytarabine is a novel cytotoxic agent and an analogue of cytarabine – the backbone of therapy of acute leukemia. Unfortunately, a substantial portion of AML patients a lack of uptake of cytarabine in leukemia cells by their lack of expression of a necessary transport protein, hENT1 on the cell membrane[ 1]. Cellular uptake of elacytarabine unlike cytarabine is independent of hENT1 , which provides a potential clinical advantage in the treatment of AML elacytarabine.

It is a segmented market with a variety of diseases. A great clinical importance is the high rate of relapse. The five-year survival rate for the most common type of acute leukemia, acute myeloid leukemia is in the range of 5-10 percent for treated elderly patients, and approximately 30 percent for treated younger adults.

The centers recruiting in Phase I were MD Anderson Cancer Center , Houston, Duke University Hospital, and University of Texas Health Science Center in San Antonio, all in the U.S. [1] Hubeek et al, Br J Cancer 2005 and Galmarini et al, Leukemia Research, 2002About Elacytarabine and nucleoside transporter – Clavis Pharma ‘s lead compound elacytarabine is a patented lipid Vector Technology version of the gold standard leukemia drug cytarabine.The Heart Institute, be studies on complex cardiovascular mechanism to identify partial. A worldwide effort into a core to the leading academic Organisations this Herzzentrum works with an international consortium that 13 new 13 new genes that increase the the risk of coronary heart disease .

– the first genic hazard factor for heart disease and said first major the new cardiovascular risk factors known ever since the discovery cholesterol Heart Institute explorer identified earlier gene 9p21. The institute was also a multitude of the other genes impact disease as atrial fibrillation and biological processes like obese is located.

Research Grange wins British Composer from the group funded by the Heart Institute or Canadian Institutes of Health Research.

– the site where hereditary information and DNA placed – A research team Grange wins British Composer discover the gene is in the nucleus been. Suggesting it behavior of other gene to control important cardiac development..