The proportion of CD8+, CD25+, FOXP3+ T cells increased by approximately 500 percent during the first course of treatment and remained elevated throughout all four courses of treatment . The amount of B cells decreased soon after the first treatment with interleukin-2 and recovered after therapy . This decrease particularly affected the IgD+ and CD27+ marginal-zone B cells that are implicated in the pathophysiology of vasculitis21 . In contrast, there was a substantial and continuous increase in the numbers of natural killer cells over time; their numbers returned to baseline amounts after discontinuation of interleukin-2 . We observed a rise in the amounts of the CD56 bright natural killer cells that create high levels of immunoregulatory cytokines and so are poorly cytotoxic22 .A number of substances have been used in an attempt to prevent the development of osteoporosis; in epidemiologic research, moderate drinking of alcoholic beverages in addition has been shown to lessen this risk. An intervention by Marrone JA et al released in Menopause, involved 40 healthy postmenopausal ladies of an average age of 56. The authors measured factors that relate to osteoporosis in post-menopausal women while topics were consuming alcohol , after they had stopped consuming, and after they experienced resumed their alcoholic beverages consumption.