After independent adjudication, the primary end stage was confirmed to have occurred in 7 patients in the closure group and 11 patients in the medical-therapy group . Results of the per-protocol analysis of the principal composite end point were like the intention-to-treat evaluation, with a hazard ratio of 0.70 . Within an analysis of the average person components of the principal end point, stroke occurred in a single patient in the closure group and five patients in the medical-therapy group , with all strokes being confirmed on neuroimaging research .Chun soon noticed, nevertheless, that the mice appeared to have an unexpected lack of white adipose tissue. Indeed, they afterwards confirmed that the only white unwanted fat the mice acquired consisted of abnormally small ‘mini-adipocytes.’ Weiss 1st suspected the mutant mice were simply malnourished because of their other deficiencies. However, the seemingly normal quantities of heat-generating brown extra fat retained by the developing mice challenged that notion.