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Strikingly, improved expression of a few of these genes, such as for example Fra-1 or Fra-2, in the liver of mice avoided the accumulation of fat and FLD completely. ‘In humans, unhealthy diet plan is the main reason behind FLD. Therefore, we utilized a fat-rich diet to induce weight problems and FLD in mice. When we started up Fra-1 in the liver, all of the fat disappeared, the effect was stunning’, states first author Sebastian Hasenfuss. Furthermore, Fra-1 prevented swelling and liver damage in obese mice also. The mechanism be described by The CNIO researchers underlying the effect of AP-1 proteins on fat metabolism. ‘AP-1 proteins are expert regulators of fat fat burning capacity’, explains corresponding writer Erwin Wagner. He provides that ‘these proteins control how the liver takes up fat from the bloodstream.’ Interestingly, the AP-1 proteins c-Fos or JunD, which are related to the Fra proteins, experienced the opposite effect on fat metabolism in the liver.