But, your fetus might have experienced irreversible damage. the damage is thought by him outcomes from the loss of life of neural crest cells, versatile cells that travel a whole lot during development, ultimately helping form bone, cartilage, connective tissue, the heart and more. These cells are developing at the same time as neural tube cells that form the brain and spinal-cord. Consequently, the telltale facial abnormalities in a newborn may foretell issues with learning also, memory, eyesight, hearing and more. Some cells need to die during development.The initial four tasks shall determine the mechanisms by which alveolar cells feeling stimuli, elucidate transmission transduction pathways elicited by these sensors and examine the consequences of the stimuli on epithelial cell sodium pump function, cell cytoskeleton and cell function and survival. The fifth project will examine the mechanisms where stretch improves non-viral gene transfer to the lung. The projects will promote development of novel equipment to investigate the downstream ramifications of these stimuli on the structure, survival and function of alveolar epithelial cells.